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Conformational Analysis of Reverse-Turn Constraints by N-Methylation and N-Hydroxylation of Amide Bonds in Peptides and Non-Peptide Mimetics

✍ Scribed by Takeuchi, Yasuo; Marshall, Garland R.


Book ID
126241948
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
204 KB
Volume
120
Category
Article
ISSN
0002-7863

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In polypeptides and proteins the peptide bond is rigid and planar and exists in the trans conformation, (I, R =H 2 and II). Some linear and cyclic peptides contain N-methylated peptide bonds which can exist in either the & or trans conformation. A necessary part of the determination of