Conformational Analysis of Peptide Libraries
β Scribed by Saul G. Jacchieri
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 47 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract For Abstract see ChemInform Abstract in Full Text.
## Synopsis A vibrational force field for the polypeptide chain has been developed for normal-mode analysis of such molecules. It can reproduce observed frequencies of known structures to within about 5 cm-l. We review the application of this technique to conformational problems in peptides (@-tur
The synthetic peptide of sequence H-Ala-Ser-Thr-Thr-Thr-Am-Tyr-Thr-OH, termed peptide T, a competitor of the Human Immunodeficiency Virus in the binding to human T cells, and its C -t d a l pentapeptide fragment, were studied by 'H-nmr in DMSO solution to determine conformational preferences. The ob
## Abstract Empirical energy calculations on __cyclo__(LβProβLβPhe) and __cyclo__(LβProβDβPhe) indicate that different conformations are possible for each molecule. The theoretical results are compared to ir, nmr, and crystallographic data. The interdependence between diketopiperazine ring and side