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Conformational analysis of N-arachidonylethanolamide (anandamide) using nuclear magnetic resonance and theoretical calculations

✍ Scribed by C. Bonechi; A. Brizzi; V. Brizzi; M. Francioli; A. Donati; C. Rossi

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
383 KB
Volume
39
Category
Article
ISSN
0749-1581

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✦ Synopsis

Abstract

The conformational properties of cis‐5,8,11,14‐eicosatetraenoylethanolamide (anandamide) were analysed by the combined use of NMR experimental results plus molecular simulations. The structure of anandamide was found to be a predominantly linear with a seven‐atom ring of the ethanolamine group having a hydrogen bond which stabilizes the molecule. The vinylic group present has a cis conformation in solution. The terminal chain has a linear conformation and undergoes isotropic fast motion typical of this structure. Copyright © 2001 John Wiley & Sons, Ltd.

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