✦ LIBER ✦

Conformational analysis of amphetamine in solution based on unambiguous assignment of the diastereotopic benzylic protons in the 1H NMR spectra

✍ Scribed by Alexandros Makriyannis; James Knittel

Publisher: Elsevier Science
Year: 1981
Tongue: French
Weight: 232 KB
Volume: 22
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)82999-3

No coin nor oath required. For personal study only.

✦ Synopsis

The erythro-and three-amphetamine-B-d diastereomers were synthesized and used for the unambiguous assignment of the diastereotopic benzylic protons and the measurement of vicinal l~-l~ coupling constants which were used to determine the distribution of rotamers around the central co-c8 bond in the side chain.

The conformation of a flexible drug in solution plays a role during its interaction with the receptor and may thus influence its pharmacological properties. 1,2 Amphetamine and some of its

📜 SIMILAR VOLUMES

Conformational Analysis of a Branched Su

Conformational Analysis of a Branched Sugar in Aqueous Solution Based on Molecular Mechanics and 1H-NMR Studies

✍ Haruo Yamada; Takeo Harada; Takashi Takahashi 📂 Article 📅 1995 🏛 Elsevier Science 🌐 French ⚖ 224 KB

Analysis of the 1H and 13C NMR spectra o

Analysis of the 1H and 13C NMR spectra of the novel macrolide antibiotic roxithromycin. Structure and conformation in solution

✍ Josyane Gharbi-Benarous; Marcel Delaforge; Isabelle Artaud; Jean-Pierre Girault 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 930 KB

## Abstract A complete assignment of the ^1^H and ^13^C NMR spectra of roxithromycin in deuteriochloroform, methanol‐__d__~4~ and D~2~O was made using different two‐dimensional (2D) chemical shift correlation methods. The coupling constants observed by ^1^H NMR and the NOEs show that the predominan

1H-NMR Of U-G-A and U-G-A-A in D2O:: Ass

1H-NMR Of U-G-A and U-G-A-A in D2O:: Assignment of nonexchangeable protons and analysis of solution conformation

✍ Michael P. Stone; Philip N. Borer 📂 Article 📅 1981 🏛 Elsevier Science 🌐 English ⚖ 602 KB

1H-NMR of G-U-C and G-U-C-C in D2O:: Ass

1H-NMR of G-U-C and G-U-C-C in D2O:: Assignment of nonexchangeable protons and analysis of solution conformation

✍ Michael P. Stone; Philip N. Borer 📂 Article 📅 1981 🏛 Elsevier Science 🌐 English ⚖ 532 KB

13C- and 1H-NMR. Spectra of ortho-benzoq

13C- and 1H-NMR. Spectra of ortho-benzoquinones. On the assignment problem in 13C spectra

✍ R. Hollenstein; Wolfgang Von Philipsborn 📂 Article 📅 1973 🏛 John Wiley and Sons 🌐 German ⚖ 167 KB 👁 1 views

## Abstract ^13^C‐ and ^1^H‐NMR. spectra of __ortho__‐benzoquinone **1** and its methyl derivatives have been analysed. By means of heteronuclear double resonance experiments it is shown that assignments given in the literature for the olefinic carbon resonances of **1** and of a series of substitu

Assignments of the 1H and 13C NMR Spectr

Assignments of the 1H and 13C NMR Spectra of Anhydroerythromycin A in Organic and Aqueous Solutions

✍ P. Alam; P. C. Buxton; K. J. Embrey; J. A. Parkinson; J. Barber 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 173 KB 👁 2 views

The 'H and "C NMR spectra of anhydroerythromycin A in methanol-d, and buffered D,O have been fully assigned using a range of one-and two-dimensional N M R techniques.