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Conformational analysis of a cyclic enkephalin analog by proton NMR and computer simulations

✍ Scribed by Mammi, Nancy J.; Hassan, Moises; Goodman, Murray


Book ID
126779687
Publisher
American Chemical Society
Year
1985
Tongue
English
Weight
659 KB
Volume
107
Category
Article
ISSN
0002-7863

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πŸ“œ SIMILAR VOLUMES


Conformational studies of diastereomeric
✍ Dale F. Mierke; Pierluigi Lucietto; Murray Goodman; Peter W. Schiller πŸ“‚ Article πŸ“… 1987 πŸ› Wiley (John Wiley & Sons) 🌐 English βš– 772 KB

## Synopsis We report the solid-phase synthesis and conformational analysis of a 14-membered, cyclic enkephalin analog, H-Tyr-~$-~-A,bu-Gly-Phe-~-Leu-] (where A,bu represents a,ydiaminobutyric acid). The results from the guinea pig ileum (GPI) and mouse vas deferens (MVD) assays show that the anal

Conformational analysis of potent sweet
✍ Ralph-Heiko Mattern; Yusuke Amino; Ettore Benedetti; Murray Goodman πŸ“‚ Article πŸ“… 1999 πŸ› Wiley (John Wiley & Sons) 🌐 English βš– 236 KB πŸ‘ 2 views

We report the conformational analysis by 1 H-nmr and computer simulations of five potent sweet molecules, N-(3,3-dimethylbutyl)-L-aspartyl-S-(␣-methyl)phenylalanine methylester (1; 5000 times more potent than sucrose), L-aspartyl-D-valine (S)-␣-methoxycarbonylmethylbenzylamide (2; 1400 times more po

A conformational comparision of two ster
✍ Dale F. Mierke; Peter W. Schiller; Murray Goodman πŸ“‚ Article πŸ“… 1990 πŸ› Wiley (John Wiley & Sons) 🌐 English βš– 622 KB

## Abstract In a continuation of our program to study the structure–activity relationship of peptide opiates, we report the conformational analysis of two cyclic tetrapeptides related to dermorphinβ€”Tyr‐c[D‐Orn‐Phe‐Asp]‐NH~2~ and Tyr‐c[D‐Asp‐Phe‐Orn]‐NH~2~. These analogues have similar binding prope