## Synopsis We report the solid-phase synthesis and conformational analysis of a 14-membered, cyclic enkephalin analog, H-Tyr-~$-~-A,bu-Gly-Phe-~-Leu-] (where A,bu represents a,ydiaminobutyric acid). The results from the guinea pig ileum (GPI) and mouse vas deferens (MVD) assays show that the anal
Conformational analysis of a cyclic enkephalin analog by proton NMR and computer simulations
β Scribed by Mammi, Nancy J.; Hassan, Moises; Goodman, Murray
- Book ID
- 126779687
- Publisher
- American Chemical Society
- Year
- 1985
- Tongue
- English
- Weight
- 659 KB
- Volume
- 107
- Category
- Article
- ISSN
- 0002-7863
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
We report the conformational analysis by 1 H-nmr and computer simulations of five potent sweet molecules, N-(3,3-dimethylbutyl)-L-aspartyl-S-(β£-methyl)phenylalanine methylester (1; 5000 times more potent than sucrose), L-aspartyl-D-valine (S)-β£-methoxycarbonylmethylbenzylamide (2; 1400 times more po
## Abstract In a continuation of our program to study the structureβactivity relationship of peptide opiates, we report the conformational analysis of two cyclic tetrapeptides related to dermorphinβTyrβc[DβOrnβPheβAsp]βNH~2~ and Tyrβc[DβAspβPheβOrn]βNH~2~. These analogues have similar binding prope