Conformational analysis of a 12-residue analogue of mastoparan and of mastoparan X

✍ Scribed by Carlos H. Faerman; Daniel R. Ripoll

• Book ID: 105358613
• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 542 KB
• Volume: 12
• Category: Article
• ISSN: 0887-3585
• DOI: 10.1002/prot.340120204

✦ Synopsis

Abstract

We have investigated the conformational properties of a truncated analogue of mastoparan and of mastoparan X, both peptides from wasp venom. The electrostatically driven Monte Carlo method was used to explore the conformational space of these short peptides. The initial conformations used in this study, mainly random ones, led to α‐helical conformations. The α‐helical conformations thus found exhibit an amphipathic character. These results are in accord with experimental data from NMR and CD spectroscopy.