Conformation transitions of blood proteins under influence of physical factors on microwave dielectric method
✍ Scribed by O.A. Gorobchenko; O.T. Nikolov; S.V. Gatash
- Book ID
- 104028317
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 323 KB
- Volume
- 102
- Category
- Article
- ISSN
- 0022-4073
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✦ Synopsis
In this article, the influence of g-irradiation and temperature on albumin and fibrinogen conformation and dielectric properties of protein solutions have been studied by the microwave dielectric method. Both the values of the real part e 0 (dielectric permittivity) and the imaginary part e 00 (dielectric losses) of the complex dielectric permittivity of the aqueous solution of bovine serum albumin and human fibrinogen as functions of temperature and g-irradiation dose have been obtained. The time of dielectric relaxation of water molecules in the protein solutions was calculated. The hydration of the albumin and fibrinogen molecules was determined. The temperature dependencies of hydration are non-monotonous and have a number of characteristic features at the temperatures 30-34 and 44-47 1C for serum albumin, and 24 and 32 1C for fibrinogen.