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Conformation studies on bombesin receptor antagonists: 500 MHz NMR and CD characterization of synthetic (D-Phe12, Leu14)-bombesin

✍ Scribed by Carlo Di Bello; Alberto Scanelli; Maria Grazia Corradini; Livio Paolillo; Enrico Trivellone; Angelo Scatturin; Gianni Vertuani; Luigia Gozzini; Roberto de Castiglione

Book ID: 115761746
Publisher: Elsevier Science
Year: 1989
Tongue: English
Weight: 445 KB
Volume: 161
Category: Article
ISSN: 0006-291X
DOI: 10.1016/0006-291x(89)91340-5

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Conformational studies on bombesin antagonists: CD and NMR characterization of [Thr6, Leu13ψ(CH2NH) Met14] bombesin (6–14)

✍ Carlo Di Bello; Angelo Scatturin; Gianni Vertuani; Gabriella D'Auria; Mario Garg 📂 Article 📅 1991 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 738 KB

## Abstract The conformational flexibility of the [Thr^6^, Leu^13^ψ(CH~2~NH) Met^14^]bombesin (6‐14) nonapeptide has been studied by CD and one‐ and two‐dimensional (1D and 2D) nmr techniques. The CD and nmr parameters in different solvents and in a micellar environment (SDS) are compared with the