Conformation of some acetylcholine analogs as solutes in deuterium oxide and other solvents
β Scribed by A. F. Casy; M. M. A. Hassan; E. C. Wu
- Publisher
- John Wiley and Sons
- Year
- 1971
- Tongue
- English
- Weight
- 816 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0022-3549
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Two conformations of cis-cyclohexyl-10-crown-3 were detected in solution below 250 K using 1H NMR at 400 MHz and 13C NMR at 100 MHz. Chemical shift assignments were facilitated by spectra of two dideuterio derivatives. From relative peak area measurements, the conformation with the unit OΓCH 2 ΓCH 2
Two conformations of the cis-cyclohexano-8-crown-3 molecule were detected at 185 K. From relative 13 C NMR peak area measurements, the conformation with the O-CH 2 -O unit equatorial was found to be favoured by 4.4 Ε‘ 0.4 kJ mol 1 . In the spectrum of the minor conformer at low temperature, a 9.6 ppm