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Conformation of peptides containing α-Aminoisobutyric acid the crystal structure of Boc-Gly-l-Ala-Aib-OMe

✍ Scribed by Bosch, Roland ;Jung, Günther ;Winter, Werner

Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
396 KB
Volume
1982
Category
Article
ISSN
0947-3440

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✦ Synopsis

Abstract

Boc‐Gly‐L‐Ala‐Aib‐OMe (1) crystallizes in the space group __P__2~1~2~1~2~1~ with a = 10.043(3), b = 11.590(5), c = 16.779(1) Å, and Z = 4 (R value for 1859 symmetry independent reflexions: 0.043). On the basis of a 4 → 1 intramolecular hydrogen bond, the tripeptide forms a β‐turn type III, although the Cα atom in the Aib residue is not directly involved in the β‐turn ring system. Inter‐molecular hydrogen bonds link the single molecules to helical structures along [100].

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