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Conformation-Odor Relationships in Norlabdane Oxides

✍ Scribed by Günther Ohloff; Christian Vial; Edouard Demole; Paul Enggist; Wolfgang Giersch; Elise Jégou; Andrew J. Caruso; Judith Polonsky; Edgar Lederer

Book ID
102858163
Publisher
John Wiley and Sons
Year
1986
Tongue
German
Weight
549 KB
Volume
69
Category
Article
ISSN
0018-019X

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✦ Synopsis

Conformational factors have been found responsible for the dramatic change in odor between (-)-deoxyambreinolide (12) and its (+)-epi derivative 13. The presumably molecular event during the receptor interaction has been simulated by the diastereoisomeric 1 1-methyl-ambrox derivatives 3 and 5 as model compounds.

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