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Conformation and activity of +H2-Pro-Leu-Gly-NH2 and its analogues modified at the leucyl residue

✍ Scribed by KIM, YOUNG JU ;HAN, SEONG JUN ;KIM, SHI CHOON ;KANG, YOUNG KEE


Book ID
115099790
Publisher
Wiley (Blackwell Publishing)
Year
2009
Tongue
English
Weight
798 KB
Volume
46
Category
Article
ISSN
0367-8377

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Conformation of the tripeptide Cbz-Pro-L
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## Abstract Chemical modifications of dual NK~1~/NK~2~ ligand Cbz‐Gly‐Leu‐Trp‐OBzl(CF~3~)~2~ (1) enabled us to create a high NK~1~ selective ligand Cbz‐Pro‐Leu‐Trp‐OBzl(CF~3~)~2~ (2). A determination of the conformational behavior of tripeptide 2 in solution is described. The 1D and 2D ^1^H‐NMR tec