✦ LIBER ✦
Conformation-activity relationships in diethylmethyl-2-[p-(o-alkyloxy-benzamido)benzoyloxy]ethylammonium bromides in solution as detected by one- and two-dimensional 1H NMR spectroscopy
✍ Scribed by Alessandro Sega; Elena Gaggelli; Gianni Valensin
- Book ID
- 102950020
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 605 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0749-1581
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✦ Synopsis
The relative conformation of the aromatic rings and the amide bridge of a series of diethyhethyb2-[p-(oa l ~l o ~~~o ) b e ~y l o ~] e t h y r a m m o n i u o n bromides has been estaMished by a combined analysis of non-selective, single-selective and double-selective pulse experiments. Relevant details of the main conformation adopted m solution by the alkyloxy and the d i e t h ~e t h y l -2 -b e n z o y l o x y e t h y l ~o ~ side-chains have been obtained by 'N1w NOE and "H two-dhnensional NMR analysis. Molecular Dreiding models were used as a basis of comparison.