Confirmation of the enantiomers of 1-methyl-1,2,3,4-tetrahydroisoquinoline in the mouse brain and foods applying gas chromatography/mass spectrometry with negative ion chemical ionization

✍ Scribed by Yukiko Makino; Yoshikazu Tasaki; Shigeru Ohta; Masaaki Hirobe

• Publisher: John Wiley and Sons
• Year: 1990
• Tongue: English
• Weight: 401 KB
• Volume: 19
• Category: Article
• ISSN: 1076-5174
• DOI: 10.1002/bms.1200190706

✦ Synopsis

With the aid of a new chiral derivatizing reagent and a sensitive and specific assay using capillary gas chromatographylnegative ion chemical ionization mass spectrometry, the proportions of R and S enantiomers of l-methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ) in mammalian tissues and foods were studied. R-and S-1MeTIQ enantiomers derivetized with a chiral derivatizing reagent, periluor~2-propoxypropionylchloride, were clearly separated. The ratio of enantiomers was RIS = 0.24, 0.55 and 0.60 in wine, cocoa and mouse brain. S-lMeTIQ predominated in all samples. This result suggested that lMeTIQ could be formed at least partially through an enzymatic mechanism.