We provide genetic evidence supporting the identity of the candidate gene for BRCA 1 through the characteri-zation of gerrnline mutations in 63 breast cancer patients and 1 0 ovarian cancer patients in ten families with cancer linked to chromosome 17q21. Nine different mutations were detected by scr
Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in ten families
โ Scribed by Friedman, Lori S.; Ostermeyer, Elizabeth A.; Szabo, Csilla I.; Dowd, Patrick; Lynch, Eric D.; Rowell, Sarah E.; King, Mary-Claire
- Book ID
- 109918864
- Publisher
- Nature Publishing Group
- Year
- 1994
- Tongue
- English
- Weight
- 626 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1061-4036
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Germline mutations in the BRCA1 and BRCA2 genes are responsible for the predisposition and development of familial breast and/or ovarian cancer. Most mutations of BRCA1 and BRCA2 associated with breast and/or ovarian cancer result in truncated proteins. To investigate the presence of BRCA1 and BRCA2
The two major hereditary breast/ovarian cancer predisposition tumor suppressor genes, BRCA1 and BRCA2 that perform apparently generic cellular functions nonetheless cause tissue-specific syndromes in the human population when they are altered, or mutated in the germline. However, little is known abo