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Confirmation of a BRAF mutation-associated gene expression signature in melanoma

✍ Scribed by Johansson, Peter ;Pavey, Sandra ;Hayward, Nicholas


Book ID
111260058
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
475 KB
Volume
20
Category
Article
ISSN
0893-5785

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## Abstract A majority of malignant melanomas harbor an oncogenic mutation in either __BRAF__ or __NRAS__. If __BRAF__ and __NRAS__ transform melanoma cells by a similar mechanism, then additional genetic aberrations would be similar (or random). Alternatively, distinct mutation‐associated changes