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Confined placental mosaicism for chromosome 7 detected by comparative genomic hybridization

✍ Scribed by B. L. Lomax; V. S. Lestou; I. J. Barrett; D. K. Kalousek

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 127 KB
Volume: 18
Category: Article
ISSN: 0197-3851
DOI: 10.1002/(sici)1097-0223(199807)18:7<752::aid-pd313>3.0.co;2-1

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✦ Synopsis

In our case, the absence of phenotypic abnormalities indicates that the supernumerary genes present in this de novo marker do not include those which are responsible for the high pathogenicity of chromosome 16 trisomy. It would be of interest to identify the loci present in this marker. This might help to define a low risk region for chromosome 16 partial trisomy and help future genetic counselling in the presence of a de novo marker of this chromosome.

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