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Configurational Entropy Change of Netropsin and Distamycin upon DNA Minor-Groove Binding

✍ Scribed by Dolenc, Jožica; Baron, Riccardo; Oostenbrink, Chris; Koller, Jože; van Gunsteren, Wilfred F.


Book ID
119919982
Publisher
Biophysical Society
Year
2006
Tongue
English
Weight
391 KB
Volume
91
Category
Article
ISSN
0006-3495

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Accessibility of the minor groove of DNA
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The interaction of the antibiotics distamycin A, distamycin analogue and netropsin with chromatin of calf thymus has been studied by circular dichroism measurements and by gel filtration. The minor groove of DNA in chromatin is accessible by 83-89% to the binding of these antibiotics as compared wit