Configuration and solvent-dependent conformation of thiaprotoberberines

✍ Scribed by P. Sohár; L. Fodor; J. Szabó; G. Bernáth

• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: English
• Weight: 359 KB
• Volume: 27
• Category: Article
• ISSN: 0749-1581
• DOI: 10.1002/mrc.1260270210

✦ Synopsis

The C-13 configmatiom of several lkarboxy-and lkarbalkoxy-thiaprotoberbanes were determined and evidence of the solvent dependence of their conformations was provided by 'H and I3C NMR and DNOE measurements.

KEY WORDS 'H NMR I3C NMR Thiaprotoberbanes C-13 configuration Solvent-dependent conformation DNOE Recently, we reported the syntheses of some novel compounds (1-5) with a protoberbane skeleton.' While determining the relative configurations of the substituents attached to C-13 and C-13a in these 13-carboxy and 13-carbalkoxy derivatives, we encountered unexpected difficulties.