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Conferring Substrate Specificity to DNA Helicases: Role of the RecQ HRDC Domain

โœ Scribed by Douglas A. Bernstein; James L. Keck


Book ID
113918465
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
563 KB
Volume
13
Category
Article
ISSN
0969-2126

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The human DNA repair protein MED1 (also known as MBD4) was isolated as an interactor of the mismatch repair protein MLH1 in a yeast two-hybrid screening. MED1 has a tripartite structure with an N-terminal 5-methylcytosine binding domain (MBD), a central region, and a C-terminal catalytic domain with