Conduction velocity is inversely related to axonal length in the median sensory nerve

✍ Scribed by Peter B.J. Wu; John Neff; Wade S. Kingery; Elaine S. Date

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 32 KB
• Volume: 21
• Category: Article
• ISSN: 0148-639X
• DOI: 10.1002/(sici)1097-4598(199802)21:2<262::aid-mus22>3.0.co;2-2

✦ Synopsis

Only two previous reports have related neuromuscular disorders on Omeprazole treatment. Sellapah 2 described a 73-year-old woman who had lower limb paresthesia, diminished pinprick sensation, and absent Achilles reflexes after a 3-month course of Omeprazole. She recovered within 10 days after the discontinuation of treatment. No electrophysiological data were reported.

Garrot et al. 1 also reported a 78-year-old woman who developed proximal weakness with reduced reflexes 14 days after initiation of Omeprazole treatment. CK was increased. A biopsy of quadriceps demonstrated type II fiber atrophy. Her weakness resolved after Omerpazole was discontinued only to recur after its reinstitution.

In our case, a causal link is suggested by the close temporal relationship between clinical symptoms and repeated Omeprazole courses. The frequency of neuromyopathy in patients treated with Omeprazole is probably very low because the drug is widely prescribed. Nonetheless, clinicians should be attentive to symptoms of neuromyopathy in this setting, as illustrated by our case.