Conducting polymer-based biosensors

✍ Scribed by A.Q. Contractor; T.N. Sureshkumar; R. Narayanan; S. Sukeerthi; Rakesh Lal; R.S. Srinivasa

• Publisher: Elsevier Science
• Year: 1994
• Tongue: English
• Weight: 294 KB
• Volume: 39
• Category: Article
• ISSN: 0013-4686
• DOI: 10.1016/0013-4686(94)e0054-4

✦ Synopsis

Abet--The electromc conductlvlty of polymers such as polyamhne exhMs a strong dependence on the redox and protonatlon state of the polymer This property has been uthsed to develop a genenc hosensor concept The concept mvolves lmmobkation of the appropriate enzyme m the conducting polymer matnx The enzyme catalyzed reaction of the homolecule results m a change m redox potential and/or pH of the nucro enwonment m the polymer matnx Thus change m the nucro enwonment tnggers a change m the electromc conductivity whch IS monitored Results shall be presented which provide proof of the above concept The systems chosen for mvestigahon are glucose/glucose oxldasc, urea/urease, neutral hpid/hpase and hemoglohn/pepsm