Conditions for the initial increase of new alleles with frequency dependent selection
โ Scribed by C. Cannings; R. Law
- Book ID
- 104698928
- Publisher
- Springer
- Year
- 1987
- Tongue
- English
- Weight
- 494 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0303-6812
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โฆ Synopsis
The paper presents the derivation of conditions for the initial increase of a new allele in a fairly general model of a one locus genetic system. Incorporated within the model are frequency dependent selection coefficients which allow the study of viability differences, fertility differences, segregation distortion and certain forms of non-random mating. Since in many models it is necessary to go beyond linear terms, quadratic, cubic and quartic terms are also derived explicitly and details given of their extension to higher degrees.
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Frequencies of mice with the rat growth hormone (rGH) transgene were examined in lines derived from two genetic bases (P/W and P/C). The genetic bases were developed from males (P) with the rGH transgene, mated with non-transgenic females of different origin: a line previously selected for large bod