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Conditional Quadratic Discrimination in the Identification of Biological Markers for Disease Screening

✍ Scribed by Dr. R. R. Rawlings; B. I. Graubard; S. Teper; R. S. Ryback; M. J. Eckardt

Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
454 KB
Volume
28
Category
Article
ISSN
0323-3847

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✦ Synopsis

Conditional multivariate normal denaity function8 am used t o conatruot conditional quadratic discriminant funotione that adjust for covariate diffemncea between dieeese groupe. An expeoted actual error rate for the conditional diaoriminant funotion is defined. The purpoee of this paper is to use the oonditional quadratio d i e o r i h n t funotion and ite misolesaifioation error rate in order to help determine if a set of discriminatore is a g+ biologioal marker for diseeee eoreening. The conditional quadratio discriminant analyeis is illuatrated using data from two alcoholism classification problem. It ia ahown how the discriminant functiona can identify a set of variables that can be used aa biologioal markem.

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