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Conditional gene targeting on the pure C57BL/6 genetic background

โœ Scribed by Masayoshi Mishina; Kenji Sakimura


Book ID
116774874
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
810 KB
Volume
58
Category
Article
ISSN
0168-0102

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An approach is described to modify yeast artificial chromosomes (YACs) with cassettes that can be easily excised for embryonic stem (ES) cell gene targeting experiments. YAC targeting technology (YTT) uses the WIBR/MIT-820 C57BL/6-mapped YAC library derived from the C57BL/6 mouse as the starting poi