Conditional and inducible gene recombineering in the mouse inner ear
β Scribed by Yong Tian; Sally James; Jian Zuo; Bernd Fritzsch; Kirk W. Beisel
- Book ID
- 113501358
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 415 KB
- Volume
- 1091
- Category
- Article
- ISSN
- 0006-8993
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## Abstract A transgenic mouse line expressing the CreER^TM^ fusion protein under the control of the __Math1__ enhancer was generated. Expression of the transgene in the postnatal mouse was restricted to hair cells of the inner ear and granule neurons in the external granule layer of the cerebellum
A newly developed desktop microtomograph was used to evaluate whether it is suitable for visualizing the three-dimensional (3D) morphology of the mouse inner ear (at a micrometer level) and whether it is applicable as a fast screening tool to detect hereditary abnormalities in this organ. To this en