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Conditional alleles in mice: Practical considerations for tissue-specific knockouts

✍ Scribed by Kin-Ming Kwan

Book ID: 102843522
Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 960 KB
Volume: 32
Category: Article
ISSN: 1526-954X
DOI: 10.1002/gene.10068

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## Abstract To study biologically relevant functions of the Janus kinase 2 (Jak2) in multiple cytokine and hormone receptor signal transduction pathways, we generated a conditional knockout (floxed) allele of this gene by placing __lox__P sites around the first coding exon of __Jak2__. Homozygous f