Condensing effect of cholesterol: A physical model

✍ Scribed by Joel L. Zatz

• Publisher: John Wiley and Sons
• Year: 1974
• Tongue: English
• Weight: 437 KB
• Volume: 63
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600630610

✦ Synopsis

A physical model is proposed to account for the "condensing effect" of cholesterol in mixed monolayers. If the other component of the monolayer has its polar groups in contact, a cholesterol molecule may interact sufficiently with the hydrocarbon tails to orient them vertically, thus creating free space for itself. In cholesterol-rich films, the polar groups of the phospholipid do not contribute to the area occupied. Both effects lead to a reduction in the observed mean molecular area.

Keyphrases 0 Cholesterol-condensing effect in mixed monolayers, physical model, equations, a-A plots Membranes-physical model proposed for condensing effect of cholesterol in mixed monolayers, equations, K-A plots o Films, monolayer-physical model proposed for condensing effect of cholesterol Monomolecular films-physical model proposed for condensing effect of cholesterol