Condensation of α-hydroxy ketones with phosphorus ylides: A convenient synthesis of linear heterocyclic formation

✍ Scribed by Wafaa M. Abdou; Yehia O. El-Khoshnieh; Azza A. Kamel

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 221 KB
• Volume: 10
• Category: Article
• ISSN: 1042-7163
• DOI: 10.1002/(sici)1098-1071(1999)10:6<481::aid-hc8>3.0.co;2-q

✦ Synopsis

Reaction of ␣-hydroxy ketones, furoin (1a) and/or benzoin (1b), with an appropriate phosphorus ylide (6a-d) provides access to new alkenes E-8a-d, 15, 16 and/or furan derivatives 11a,b and 21. Furthermore, reaction of 1a,b with arylidenephosphorane 7 led to the formation of the respective dioxolo compound 22a,b.