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Concurrent and Independent HCO−3and Cl−Secretion in a Human Pancreatic Duct Cell Line (CAPAN-1)

✍ Scribed by H.S. Cheng; P.Y. Leung; S.B. Cheng Chew; P.S. Leung; S.Y. Lam; W.S. Wong; Z.D. Wang; H.C. Chan

Book ID
105927389
Publisher
Springer
Year
1998
Tongue
English
Weight
255 KB
Volume
164
Category
Article
ISSN
0022-2631

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## Abstract Exendin‐4 (EX‐4), a long acting agonist of GLP‐1, induces an endocrine phenotype in Capan‐1 cells. Under culture conditions which include serum, ∼10% of the cells contain insulin and glucagon. When exposed to EX‐4 (0.1 nM, up to 5 days), the number of cells containing insulin and glucag