Concrement formation in the urinary bladder in rats inoculated with Ureaplasma urealyticum

✍ Scribed by Grenabo, L. ;Brorson, J.-E. ;Hedelin, H. ;Pettersson, S.

• Book ID: 104689370
• Publisher: Springer
• Year: 1985
• Tongue: English
• Weight: 344 KB
• Volume: 13
• Category: Article
• ISSN: 0300-5623
• DOI: 10.1007/bf00261823

✦ Synopsis

To study the concrement-forming ability of Ureaplasma urealyticum in the urinary tract, viable and heat-killed ureaplasmas as well as urease and non-urease-producing bacteria were inoculated into the bladder in rats. Viable ureaplasmas, in contrast to heat-killed, caused the formation of bladder stones with a frequency corresponding to urease-producing bacteria (Proteus mirabilis). It was not possible to reculture the inoculated ureaplasmas from the urinary tract. Non-urease producing microorganisms (Escherichia coli and Mycoplasma hominis) only occasionally induced stone formation. The results indicate that U. urealyticum can initiate stone formation, a property that appears to be associated with the urease activity of the organism.