## Abstract Both hypermethylation of the tumor suppressor gene __RASSF1A__ and activating mutations of the __KRAS__ and/or __BRAF__ gene have been reported in a variety of human cancers. To investigate these epigenetic and genetic alterations in endometrial carcinoma (EC), we examined their frequen
✦ LIBER ✦
Concomitant RASSF1A hypermethylation and KRAS/BRAF mutations occur preferentially in MSI sporadic colorectal cancer
✍ Scribed by Oliveira, Carla; Velho, Sérgia; Domingo, Enric; Preto, Ana; Hofstra, Robert M W; Hamelin, Richard; Yamamoto, Hiroyuki; Seruca, Raquel; Schwartz, Simo
- Book ID
- 110069948
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 175 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0950-9232
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## Abstract Recently, __RASSF2A__ was identified as a potential tumor suppressor epigenetically inactivated in human cancers. Here, we evaluated the methylation status of __RASSF2A__ in colorectal cancer (CRC) and analyzed its correlation with K‐__ras__/__BRAF__ mutations, microsatellite instabilit