Concomitant radiation therapy and targeted cisplatin chemotherapy for the treatment of advanced pyriform sinus carcinoma: Disease control and preservation of organ function
✍ Scribed by Sandeep Samant; Parvesh Kumar; Jim Wan; Cathy Hanchett; Francisco Vieira; Tom Murry; Frank S.H. Wong; K. Thomas Robbins
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 82 KB
- Volume
- 21
- Category
- Article
- ISSN
- 1043-3074
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✦ Synopsis
Background. Squamous cell carcinoma of the pyriform sinus is an unfavorable disease which frequently presents in advanced stages. Despite aggressive "standard treatment" involving debilitating surgery and postoperative radiation therapy treatments, the survival and functional outcome for pyriform sinus carcinoma remains poor. Hence, we reviewed our experience in the management of advanced pyriform sinus carcinoma using "organ preservation" chemoradiation therapy.
Methods. Twenty-five patients diagnosed with stage III/IV pyriform sinus squamous cell carcinoma treated with supradose, intra-arterial targeted cisplatin, and concomitant radiotherapy were analyzed for response rates, survival, pattern of failure, and