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Concomitant activation of extracellular signal-regulated kinase and induction of COX-2 stimulates maximum prostaglandin E2 synthesis in human airway epithelial cells

✍ Scribed by Nenad Petrovic; Darryl A. Knight; John S. Bomalaski; Philip J. Thompson; Neil L.A. Misso


Book ID
113865019
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
416 KB
Volume
81
Category
Article
ISSN
0090-6980

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## Abstract Overexpression of cyclooxygenase‐2 (COX‐2) and elevation of its derivative prostaglandin E~2~ (PGE~2~) are implicated in human esophageal squamous cell carcinoma. The expression of c‐Myc, an oncogenic transcription factor, is also upregulated in this malignant disease. This study sought