Concise synthesis of taxol a-ring components: Remote diastereoselective additions of alkenyl lithiums to aldehydes

✍ Scribed by Christopher Frost; Patrick Linnane; Philip Magnus; Mark Spyvee

• Book ID: 104255944
• Publisher: Elsevier Science
• Year: 1996
• Tongue: French
• Weight: 268 KB
• Volume: 37
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(96)02159-4

✦ Synopsis

The acid chloride 6 provides access to 7 (R,S and S,S) which upon bromine-lithium exchange undergoes remarkably highly diastereoselective additions to aldehydes; 7 is also readily elaborated into the acetal 10.