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Concise Synthesis of (−)-Nakadomarin A

✍ Scribed by David B. C. Martin; Christopher D. Vanderwal


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
360 KB
Volume
49
Category
Article
ISSN
0044-8249

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A Concise Synthesis of Fumagillol
✍ David A. Vosburg; Sven Weiler; Erik J. Sorensen 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 100 KB 👁 1 views

A 13-step synthesis of (±)-fumagillol (1), the direct precursor of the potent angiogenesis inhibitors TNP-470 and fumagillin, from crotonaldehyde, diethylamine, and acrolein (see the scheme) has been achieved. The synthesis features a remarkable hetero-Claisen rearrangement. Small-molecule inhibitor