Concise synthesis of 6-sulfonylated 3,4-dihydro-2h-thiopyrans and 7-sulfonylated 3,4,5,6-tetrahydrothiepines from lactols

✍ Scribed by John K. Gallos; Constantinos C. Dellios

• Book ID: 102345159
• Publisher: Journal of Heterocyclic Chemistry
• Year: 2001
• Tongue: English
• Weight: 70 KB
• Volume: 38
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.5570380304

✦ Synopsis

Abstract

A concise method for the synthesis of the title compounds has been developed, which involves condensation of lactols with methylthiomethyl p‐tolyl sulfone, followed by mesylation and further cyclisation of the elimination products by refluxing with excess of sodium iodide in dimethyl formamide (DMF).