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Concise Review: Telomere Biology in Normal and Leukemic Hematopoietic Stem Cells

✍ Scribed by Mark W. Drummond; Stefan Balabanov; Tessa L. Holyoake; Tim H. Brummendorf

Book ID
111845699
Publisher
AlphaMed Press
Year
2007
Tongue
English
Weight
318 KB
Volume
25
Category
Article
ISSN
1066-5099

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## Abstract Chronic Myeloid Leukemia (CML), a myeloproliferative disease of stem cell origin, is characterized by the presence of the Philadelphia (Ph) chromosome and the __bcr‐abl__ oncogene. The BCR‐ABL fusion gene product, thought to be causative in CML, has multiple effects on diverse cell func