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Concise, efficient and practical assembly of bromo-5,6-dimethoxyindole building blocks

โœ Scribed by Paul B. Huleatt; Jacelyn Lau; Sheena Chua; Yun Lei Tan; Hung Anh Duong; Christina L.L. Chai


Book ID
104098859
Publisher
Elsevier Science
Year
2011
Tongue
French
Weight
338 KB
Volume
52
Category
Article
ISSN
0040-4039

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โœฆ Synopsis


A concise, efficient and simple route to a series of bromoindole building blocks is described. The synthetic routes are highlighted by purification-free preparation of o-nitrocinnamate intermediates and clean, modified Cadogan indole syntheses. The scope of this indole synthesis has been explored and expanded through the use of a range of solvents and easily removable phosphine reagents.


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