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Concise asymmetric synthesis of a (1R,2S)-1-amino-2-vinylcyclopropanecarboxylic acid-derived sulfonamide and ethyl ester

✍ Scribed by Lou, Sha; Cuniere, Nicolas; Su, Bao-Ning; Hobson, Lindsay A.


Book ID
121196336
Publisher
Royal Society of Chemistry
Year
2013
Tongue
English
Weight
836 KB
Volume
11
Category
Article
ISSN
1477-0520

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An efficient and easy one-pot reaction from readily available racemic 2-substituted cyclobutanones gave, by means of asymmetric Strecker synthesis in the presence of an amine chiral auxiliary, two major aminonitriles with excellent diastereoselectivity. After separation, the major cis-aminonitriles