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Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum

✍ Scribed by Saveanu, Loredana; Carroll, Oliver; Lindo, Vivian; Del Val, Margarita; Lopez, Daniel; Lepelletier, Yves; Greer, Fiona; Schomburg, Lutz; Fruci, Doriana; Niedermann, Gabriele

Book ID: 109923104
Publisher: Nature Publishing Group
Year: 2005
Tongue: English
Weight: 350 KB
Volume: 6
Category: Article
ISSN: 1529-2908
DOI: 10.1038/ni1208

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## Abstract Studies with in‐vitro‐cultured neurons treated with amyloid‐β (Aβ) peptides demonstrated neuronal loss by apoptosis that is due, at least in part, to the perturbation of intracellular Ca^2+^ homeostasis. In addition, it was shown that an endoplasmic reticulum (ER)‐specific apoptotic pat