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Concerted Intercalation and Minor Groove Recognition of DNA by a Homodimeric Thiazole Orange Dye

โœ Scribed by Bunkenborg, Jakob; Gadjev, Nikolai I.; Deligeorgiev, Todor; Jacobsen, Jens Peter


Book ID
127105592
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
99 KB
Volume
11
Category
Article
ISSN
1043-1802

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## Abstract Crescentโ€shaped polyamides composed of aromatic amino acids, __i.e.__, 1โ€methylโ€1__H__โ€imidazole **Im**, 1โ€methylโ€1__H__โ€pyrrole **Py**, and 3โ€hydroxyโ€1__H__โ€pyrrole **Hp**, bind in the minor groove of DNA as 2โ€‰:โ€‰1 and 1โ€‰:โ€‰1 ligand/DNA complexes. DNAโ€Sequence specificity can be attribut