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Concerted Dephosphorylation of the Transcription Factor NFAT1 Induces a Conformational Switch that Regulates Transcriptional Activity

✍ Scribed by Heidi Okamura; José Aramburu; Carmen García-Rodríguez; João P.B. Viola; Anuradha Raghavan; Mamta Tahiliani; Xiaolong Zhang; Jun Qin; Patrick G. Hogan; Anjana Rao

Book ID: 117735944
Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 467 KB
Volume: 6
Category: Article
ISSN: 1097-2765
DOI: 10.1016/s1097-2765(00)00053-8

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## Abstract Dmp1 (Dmtf1) encodes a Myb‐like transcription factor implicated in tumor suppression through direct activation of the Arf‐p53 pathway. The human __DMP1__ gene is frequently deleted in non‐small cell lung cancers, especially those that retain wild‐type __INK4a/ARF__ and/or __p53__. To id