Concerning the structure of 7α,15β-dichloro-5α-cholest-8(14)-en-3β-ol, a novel inhibitor of cholesterol biosynthesis
✍ Scribed by Marcia E. Newcomer; G.L. Gilliland; Edward J. Parish; George J. Schroepper Jr.; Florante A. Quiocho
- Book ID
- 107736968
- Publisher
- Elsevier Science
- Year
- 1980
- Tongue
- English
- Weight
- 394 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0009-3084
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The chemical synthesis of 3 beta-p-bromobenzoyloxy-15 beta-methyl-5 alpha,14 beta-cholest-7-en-15 alpha-ol from 15 beta-methyl-5 alpha, 14 beta-cholest-7-ene-3 beta,15 alpha-diol is described. The structure of the former compound was unambiguously determined by X-ray crystallographic analysis. The s
Treatment of 3~-benzoyloxy-14c¢,l 5~-epoxy-5a-cholest-7-ene (I) with gaseous HCI in chloroform at 40°C gave, in 87% yield, 3#-benzoyloxy-7a,1513-dichloro-5a-cholest-8(14)-ene (111). Reduction of the latter compound with lithium aluminum hydride in ether at room temperature for 20 min gave, in 86% yi