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Conceptual underestimation of the total body clearance by the sum of clearances of individual organs in physiologically based pharmacokinetics

โœ Scribed by Leonid M. Berezhkovskiy


Book ID
115559238
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
136 KB
Volume
101
Category
Article
ISSN
0022-3549

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Physiologically based pharmacokinetic mo
โœ Frans G. M. Russel; Alfons C. Wouterse; Cees A. M. Van Ginneken ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 704 KB

Plasma kinetics and renal excretion of iodopyracet (3\*0g, adminstered i.v.) with and without concomitant administration of probenecid were studied in the beagle dog. Pharmacokinetic analysis revealed that tubular secretion is the predominant route of excretion, and that secretion is inhibited by pr