Concepts in Clinical Pharmacokinetics

✍ Scribed by Robin Southwood, Virginia H. Fleming, Gary Huckaby

• Publisher: American Society of Health-System Pharmacists
• Year: 2018
• Tongue: English
• Leaves: 295
• Edition: 7th Edition
• Category: Library

✦ Synopsis

Understanding the science of pharmacokinetics is a challenge for many pharmacy students and practitioners. Concepts in Clinical Pharmacokinetics, now in its 7th edition, has helped thousands by simplifying this essential, but complex, subject to reflect current practice.

The 7th edition has been revised by Robin Southwood, PharmD, BC-ADM, CDE; Virginia H. Fleming, PharmD, BCPS; and Gary Huckaby, PharmD; all experts in clinical pharmacy education. Together, they have updated and expanded the text to include the latest information and insights on concepts through extensive use of correlates, figures, and review questions.

Inside you will find:

• 15 easy-to-follow lessons, perfect for a semester
• Practice quizzes to help chart progress
• Enhanced discussion of hemodialysis
• A phenytoin “cheat sheet” to help you through the calculations maze
• New vancomycin cases based on higher desired vancomycin levels and trough-only dose estimations
• Expanded information on modified diet in renal disease formula versus Cockcroft-Gault formula methods
• Factors to consider when choosing a dosing/body weight for various equations
• Updated clinical correlates, discussion points, references, and questions/answers

Concepts in Clinical Pharmacokinetics is the fundamental reference for learning the basic, foundational pharmacokinetics concepts and how to apply them in clinical practice.

✦ Table of Contents

Title Page......Page 2
Copyright......Page 3
Table of Contents......Page 4
Preface......Page 6
A Note from the Authors on Using This Edition......Page 8
Abbreviations......Page 10
Lesson 1. Introduction to Pharmacokinetics and Pharmacodynamics......Page 12
Lesson 2. Basic Pharmacokinetics......Page 32
Lesson 3. Half-Life, Elimination Rate, and AUC......Page 42
Practice Set 1......Page 56
Lesson 4. Intravenous Bolus Administration, Multiple Drug Administration, and Steady-State Average Concentrations......Page 60
Lesson 5. Relationships of Pharmacokinetic Parameters and Intravenous Intermittent and Continuous Infusions......Page 76
Lesson 6. Two-Compartment Models......Page 92
Practice Set 2......Page 104
Lesson 7. Biopharmaceutics: Absorption......Page 110
Lesson 8. Drug Distribution and Protein Binding......Page 124
Lesson 9. Drug Elimination Processes......Page 136
Lesson 10. Nonlinear Processes......Page 156
Lesson 11. Pharmacokinetic Variation and Model-Independent Relationships......Page 166
Practice Set 3......Page 182
Lesson 12. Aminoglycosides......Page 186
Lesson 13. Vancomycin......Page 214
Lesson 14. Theophylline......Page 232
Lesson 15. Phenytoin and Digoxin......Page 242
Appendix A. Basic and Drug-Specific Pharmacokinetic Equations......Page 262
Appendix B. Supplemental Problems......Page 272
Appendix C. Glossary......Page 280
Index......Page 284

✦ Subjects

Clinical Pharmacy