Concentricolide, an Anti-HIV Agent from the Ascomycete Daldinia concentrica

✍ Scribed by Xiang-Dong Qin; Ze-Jun Dong; Ji-Kai Liu; Liu-Meng Yang; Rui-Rui Wang; Yong-Tang Zheng; Yang Lu; Yun-Shan Wu; Qi-Tai Zheng

• Book ID: 102253297
• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: German
• Weight: 120 KB
• Volume: 89
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.200690004

✦ Synopsis

A novel benzofuran lactone, named concentricolide (= rel-(6R)-6-ethylbenzo[2,1-b:3,4-c']difuran-8(6H)-one; 1), was isolated along with four known compounds (friedelin, cytochalasin L-696,474, armillaramide, and russulamide) from the fruiting bodies of the xylariaceous ascomycete Daldinia concentrica. The structure of 1 was established by spectroscopic methods and X-ray crystallographic analysis. Its anti-HIV-1 activity was tested. Results showed that 1 inhibited HIV-1 induced cytopathic effects. The EC 50 value was 0.31 mg/ml. The therapeutic index (TI) was 247. Concentricolide exhibited the blockage (EC 50 0.83 mg/ml) on syncytium formation between HIV-1 infected cells and normal cells.