Concentrations of vinblastine in human intracerebral tumor and other tissues
β Scribed by David J. Stewart; Katherine Lu; Robert S. Benjamin; Milam E. Leavens; Mario Luna; Hwee-Yong Yap; Ti Li Loo
- Publisher
- Springer US
- Year
- 1983
- Tongue
- English
- Weight
- 390 KB
- Volume
- 1
- Category
- Article
- ISSN
- 0167-594X
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Vinzolidine (VZL), a semisynthetic vinblastine (VLB) derivative, was tested against a variety of solid tumors in the human tumor clonogenic assay (HTCA). The emphasis was on continuous drug exposure because of the schedule-dependency of the vincas and long half-life of VZL. Of tumor types with more
Human tissues (bone, hair, liver and kidney) from 61 individuals, collected post-mortem, were analyzed by energydispersive x-ray Γuorescence (EDXRF) spectrometry. All samples were analyzed without any chemical treatment. The soft tissues (liver and kidney) were lyophilized and ground in an agate mor