Concentrations of soluble vascular cell adhesion molecule-1 and E-selectin in breast cyst fluid and their relation with cyst type

✍ Scribed by Dr L. C. Lai; A. K. Siraj; S. Kadory; T. W. J. Lennard

• Publisher: John Wiley and Sons
• Year: 1995
• Tongue: English
• Weight: 273 KB
• Volume: 82
• Category: Article
• ISSN: 0007-1323
• DOI: 10.1002/bjs.1800820129

✦ Synopsis

Abstract
Gross cystic breast disease may be associated with a higher risk of breast cancer. There are two groups of mammary cysts: those lined by apocrine epithelium (intracystic sodium to potassium (Na:K) ratio < 3) and those lined by flattened epithelium (intracystic Na:K ratio > 3). Cell adhesion molecules may be involved in various stages of tumour metastasis. Intracystic levels of soluble vascular cell adhesion molecule-1 (sVCAM-1) and soluble E-selectin (sE-selectin) were measured. Significantly greater concentrations of sVCAM-1 and sE-selectin occurred in the high-electrolyte ratio group than in the low (P <0·001). A positive correlation was found between sVCAM-1 and sE-selectin (rS = 0·827, P <0·001) which may be a chance observation or suggest a common mechanism of entry into mammary cysts. The significance of these soluble cell adhesion molecules in breast cyst fluid requires elucidation.