Concentration of meropenem in serum and in bronchial secretions in patients undergoing fibreoptic bronchoscopy

✍ Scribed by E. Bergogne-Bérézin; C. Muller-Serieys; M. Aubier; M. C. Dombret

• Publisher: Springer
• Year: 1994
• Tongue: English
• Weight: 227 KB
• Volume: 46
• Category: Article
• ISSN: 0031-6970
• DOI: 10.1007/bf00195922

✦ Synopsis

The objective of the study was to evaluate the ability of meropenem to reach the bronchial lumen. 24 patients undergoing fibreoptic bronchoscopy for exploratory purposes were given a single dose of meropenem 1 g as an ( i.v., infusion over 30 min. Plasma (P) sampling times were: 0, 0.5, 1, 2 and 3 h. Bronchial secretions (BS) were collected by fibreoptic bronchoscopy at the same sampling times (except for 0 and 0.5 h) in three groups of 8 patients. Meropenem was measured by bioassay using E. coli ATCC 39 118 as the test-organism.

The results showed that meropenem had reached a high plasma concentration at the first sampling time (59.8 mg. 17) and then the plasma level decreased rapidly to 10.6 mg-kl and 2.7 mg. 14 at 2 and 3 h respectively. The highest concentration achieved in bronchial secretion was 0.53 mg. 1-1 in the third hour, ie 20 % of the serum level.

The data indicate significant penetration ofmeropenem into bronchial secretions and achievement of a local level sufficiently high to eradicate most respiratory pathogens.